积雪苷片在瘢痕疙瘩切除并放疗后的应用

Application of asiaticoside tablet on keloid patients treated with surgery and radiation

目的探讨积雪苷片针对瘢痕疙瘩切除并放疗后增生性瘢痕和瘢痕疙瘩等病理性瘢痕形成的预防作用,以及促进局部色素的消退作用。方法 129例瘢痕疙瘩患者随机分为积雪苷片治疗组(n=71)和对照组(n=58)。治疗6个月后,所有患者均随访6～12个月,根据瘢痕增生或瘢痕疙瘩复发情况以及色素沉着消退时间等进行疗效评价。结果积雪苷片治疗组瘢痕增生的发生率为1.48%,显著低于对照组10.58%(P<0.05)。积雪苷片治疗组色素消退平均时间为(4.71±0.89)个月,短于对照组(7.10±0.98)个月(P<0.05)。结论积雪苷片口服对瘢痕疙瘩切除并放疗后的增生性瘢痕和瘢痕疙瘩复发等病理性瘢痕形成具有预防作用,并能缩短局部色素沉着的恢复时间。

Objective To observe the prophylactic effects of asiaticoside tablet on scar recurrence and skin pigmentation in keloid patients treated with surgery and radiation. Methods Analyzing the clinical data of 129 keloid patients treated in our center. All the patients were treated with keloid excision and adjacent radiation. After operation, patients were randomly devided into asiaticoside tablet treatment group （n=71） and control group （n=58）. In the 6-12 months of following time after 6 months treatment, their scar recurrence and skin pigmentation were observed and compared. Results There was significant difference between asiaticoside tablet treatment group and control group, scar recurrence rates in two groups were 1.48% and 10.58% respectively （P〈0.05）, and skin color resuming in two groups were （4.71 ± 0.89） months and （7.10 ±0.98） months, the difference is obvious （P〈 0.05）. Conclusion Asiaticoside tablet orally taken after operation can prevent from scar recurrence and decrease the skin pigmentation in keloid patients treated with surgery and radiation.