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他汀类药物中间体(S)-4-氯-3-羟基丁酸乙酯生物催化合成的研究进展 被引量：2

Research progress on biocatalysis of (S)-4-chloro-3-hydroxybutanoate esters used for the intermediates of statins drugs
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摘要 (S)-4-氯-3-羟基丁酸乙酯[(S)-CHBE]是羟甲戊二酰辅酶A还原酶抑制剂即他汀类药物的关键手性中间体。本文综述生物催化合成(S)-CHBE的研究进展。 （S） -4-chloro-3-hydroxybutanoate ester [ （S）-CHBE] is a key chiral intermediate of cholesterol-lowering drugs, 3-hydroxy-3-methyl-glutaryl CoA reductase inhibitors. This review summerizes the screening of microorganisms responsible for the biocatalysis of COBE to （S） -CHBE through the gene cloning of carbonyl reductases.
作者 陶源 胡又佳 周斌 朱宝泉
机构地区 中国医药工业研究院总院上海医药工业研究院创新药物与制药工艺国家重点实验室
出处 《世界临床药物》 CAS 2013年第6期359-363,共5页 World Clinical Drug
基金 国家"重大新药创制"(项目编号:2012ZX9301002003-004)
关键词 (S)-4-氯-3-羟基丁酸乙酯 他汀类药物 生物催化 ethyl （S） -4-chloro-3-hydroxybutanoate ester statins biocatalysis
分类号 R972.6 [医药卫生—药品]
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参考文献46

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二级参考文献89

共引文献29

同被引文献21

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世界临床药物
2013年 第6期

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