摘要
聚合物胶束具有增溶难溶性药物、选择性靶向、P-gp抑制以及改变药物摄取途径等特点,作为药物传递系统具有广泛的应用前景。本文着重综述载药聚合物胶束的制备方法与肿瘤靶向策略的研究现状及进展。
Polymeric micelles represent one of the promising drug delivery systems.They are characterized by core-shell structures which assure the solubility of poorly water soluble drugs and enhance stability in bloodstream.Many preparation methods were used to obtain polymeric micelles with high drug loading.Polymeric micelles can be accumulated in tumors and pathological sites by passive,physical or active targeting.
出处
《北方药学》
2013年第6期61-63,共3页
Journal of North Pharmacy
关键词
聚合物胶束
药物传递系统
靶向
polymeric micelles
drug delivery systems
targeting
