C反应蛋白在急性阑尾炎严重程度评估中的作用

C-reactive protein in assessment of severity of acute appendicitis

目的探讨血液中炎症标记物在急性阑尾炎诊断及病情评估中的意义。方法回顾性分析我院2012年1月～2012年12月收治的135例急性阑尾炎患者的临床资料,统计其白细胞计数(WBC),中性粒细胞的百分比(NEUT%),C-反应蛋白(CRP)水平以及术后并发症发生率。结果非坏死性阑尾炎组(急性单纯性阑尾炎和急性化脓性阑尾炎)和坏死性阑尾炎组(急性坏疽性阑尾炎)的CRP水平分别为:(26.7±14.2)mg/L和(56.6±28.4)mg/L,后者高于前者且差异有统计学意义(P<0.05);后者并发症报告率16.7%(7/42例)高于前者的4.3%(4/93例),差异有统计学意义(P<0.05)。其白细胞计数(WBC)和中性粒细胞的百分比(NEUT%),2组间差异无显著性(P>0.05)。结论 CRP水平在急性坏疽性阑尾炎患者中明显升高,有助于判断阑尾炎的严重程度。

Objective To investigate the significance of blood inflammatory markers in the diagnosis of acute appendicitis and condition assessment.Methods Clinical data of 135 cases of acute appendicitis in our hospital between January 2012 to December 2012 were reviewed.The white blood cell counts（WBC）,the percentage of neutrophils（NEUT%）,the C-reactive protein（CRP） level and the incidence of postoperative complications were assessed and analyzed.Results The CRP levels in the non-necrotizing appendicitis group（catarrhalis and phlegmonous appendicitis） and necrotizing appendicitis group（gangrenous appendicitis） were 26.7 ± 14.2mg / L and 56.6 ± 28.4mg / L respectively.The latter was higher than the former,and the difference was statistically significant（P 0.05）.The reporting complication rate of the latter was 16.7%（7 /42） which was higher than the former（4.3%,4 /93,P 0.05）.The white blood cell counts（WBC） and neutrophil percentage（NEUT%） between the two groups had no significant difference.Conclusion The CRP level in patients with acute gangrenous appendicitis is significantly increased,which contributes to the assessment of the severity of appendicitis.