摘要
目的通过检测乳腺癌组织中Ki67的表达水平,探讨Ki67与各临床病理指标之间的关系及临床意义。方法收集河北医科大学第四医院乳腺外科原发性乳腺癌患者术后标本2390例,对Ki67与临床病理因素进行相关性分析。结果 Ki67与绝经情况无相关(P>0.05);与年龄、肿瘤大小、病理分期、病理类型、脉管瘤栓、组织分级、淋巴结转移、ER、PR、HER-2、Ki67、p53均有相关性(P<0.05)。结论 Ki67阳性表达可以作为判断乳腺癌生物学行为的重要指标。
Objective By means of the detection of expression levels of Ki67, to investigate the correlation between the expression of Ki67 and clinical pathological parameters as well as its clinical significance. Methods The 2 390 postoperative specimens of patients with primary breast cancer in Department of Breast Surgery,The Fourth Hospital of Hebei Medical University were collected from January 1,2009 to December 31, 2010. The correlation between Ki67 and clinical pathological factors was analyzed. Results The expression levels of Ki67 were not related with menostasia （ P 〉 0. 05 ） , however, which were correlated to patients＇ age, tumor＇ s size, pathological stage, pathological type, vascular tumor thrombus, pathological grade, lymph node metastasis, ER, PR, HER-2,p53 （ P 〈 0.05 ）. Conclusion The positive expression of Ki67 can be regarded as an important index for evaluating biological behavior of breast cancer.
出处
《河北医药》
CAS
2013年第12期1769-1771,共3页
Hebei Medical Journal
