辛伐他汀治疗急性心肌梗死的疗效及其对血液流变学的影响

Curative Effects of Simvastatin in the Treatment of Acute Myocardial Infarction and its Influence on Hemorheology

目的探讨辛伐他治汀疗急性心肌梗死(AMI)的疗效和对患者血液流变学的影响。方法我院于2010年6月至2012年6月共收治AMI患者95例,按照治疗方式将患者分为对照组和观察组:对照组43例,给予溶栓、抗凝、抗心力衰竭等常规治疗;观察组52例,在常规治疗的基础上睡前给予辛伐他汀20 mg/d。4周后对两组患者治疗有效率和血液流变学指标(纤维蛋白原浓度、血浆黏度、全血高切、低切黏度、血小板凝集率)进行比较分析。结果观察组治疗有效率明显高于对照组(P<0.05)。对照组治疗后纤维蛋白原浓度、血浆黏度、全血高切、低切黏度及血小板凝集率等指标较治疗前比较无统计学意义(P>0.05)。观察组治疗后纤维蛋白原浓度、血浆黏度、全血高切、低切黏度及血小板凝集率等指标明显低于治疗前和对照组,差异有统计学意义(P<0.05)。结论血液流变学异常与AMI的发生存在密切关系,辛伐他汀可改善AMI患者血液流变学指标。

Objective To explore curative effects of simvastatin in the treatment of acute myocardial infarction and its influence on hemorheology. Methods 95 patients with acute myocardial infarction from June 2010 to June 2012 were divided randomly into control group and observe group. Patients in the control group were treated with routine therapy. Patients in the observe group were treated with simvastatin on the basis of routine therapy. The total effective rate and hemorheology index in the control group and observe group were analyzed. Results The total effective rate in the observe group were significantly higher than that in the con- trol group （ P 〈 0.05 ）. Compared with before treatment, the hemorheology index （ fibrinogen, plasma viscosity, blood viscosity, platelet agglutination） had no significantly difference in the control group after treatment （ P 〉 0. 05 ）. The hemorheology index in the observe group after treatment significantly decreased than that before treatment and control group after treatment （P 〈 0.05 ）. Conclusion There is close relationship abnormal he- morheology and acute myocardial infarction. Simvastatin can significantly improve hemorheology index.