循证护理在预防紫杉醇对卵巢癌化疗致过敏反应中的应用

Application of evidence-based nursing in prevention of allergic reaction induced by taxol in ovarian cancer

目的:探讨循证护理在预防紫杉醇对卵巢癌化疗致过敏反应中的应用效果。方法:对2010年1～9月(循证护理实施前)紫杉醇对卵巢癌化疗致过敏反应的情况进行分析,应用计算机网络检索相关文献,并对资料的真实性、可靠性及临床实用性作出评价,确定结论,制定防范措施,并在2010年10月～2011年7月实施,比较循证护理前后两组患者过敏反应发生率。结果:实施循证护理前后两组患者过敏反应发生率分别为9.0%和3.8%,两组比较差异有统计学意义(P<0.05)。结论:实施循证护理大大降低了紫杉醇对卵巢癌化疗致过敏反应的发生率,保证了化疗用药的安全性。

Objective： To investigate the effect of evidence - based nursing in prevention of allergic reaction induced by taxol in ovarian cancer patients. Methods ： We analsed allergic reactions induced by tsxol in ovarian cancer patients from January 2010 to September 2010 （ before evidence - based nursing was performed）, and searched related literatures, then we evaluated the authenticity, reliabiliy, and clinical applicability of the evidence, at last the conlu- sion and preventive nursing intervention were ascertained. Thereafter we applied evidence - based nursing to ovarian cancer patients who were taking taxol chemotherapy from October 2010 to July 201 1, and we compared the incidence of allergic reation. Results： The incidence rae of allergic reaction before and after evidence - based nursing was 9.0% and 3.8% respectively, the difference was statistically significant （ P 〈 0.05 ）. Conclusion： Application of evi- dence - based nursing can reduce allergic reaction induced by taxol in ovarian cancer patients, thus the safety of chemotherapeutic drugs is ensured.