2型糖尿病患者血小板α-颗粒膜蛋白与肾脏病变的关系

Relationship between change in content of plateletα-granule membrane protein and nephropathy in type2 diabetic patients

目的 探讨 2型糖尿病患者血小板α 颗粒膜蛋白 (GMP 140 )含量变化与肾脏病变的关系。方法 测定 349例 2型糖尿病患者血小板GMP 140、纤维蛋白原 (Fg)、尿白蛋白 (Alb)、血和尿α1微球蛋白 (α1 MG) ,并与 5 0例健康者作对照 ;对 5 1例糖尿病肾病 (DN)患者在治疗糖尿病的同时 ,应用抗血小板活性药物。结果 无糖尿病肾病 (NDN)组血小板GMP 140含量高于正常对照组 ,但低于DN组 ,5 1例DN患者经过治疗后肾功能明显好转。结论 血小板GMP 140含量变化与

ObjectiveToinvestigatetherelationshipbetweenthechangeinplateletα granule membraneprotein(GMP 140 )contentanddiabeticnephropathy(DN)intype 2diabeticpatients.Methods TodeterminetheplateletGMP 140 ,fibrinogen(Fg) ,urinaryalbumin(Alb) ,α1 microglobulin(α1 MG)in bloodandurinein 349type 2diabeticpatientsandcomparedwiththoseof 5 0normalcontrols .Forthe 5 1 DN ,anti plateletactivitymedicinewasgivenwhileactivemeasuresweretakentocontrolthebloodglucose. Results ThecontentofplateletGMP 140innon diabeticnephropathygroupwashigherthanthatofnor malcontrolgroupbutlowerthanthatofDNgroup .Aftertreatment,the 5 1DNpatientsshowedimprove mentapparentlyinrenalfunction .Conclusion ThechangeintheplateletGMP 140contentoftype 2dia beticpatientsiscloselyrelatedtothedevelopmentofDN .