生脉注射液治疗血液透析相关性低血压临床观察

Shengmai injection in the treatment of patients with uremia combined with cardiac insufficiency hypotension correlation by dialysis

目的观察生脉注射液治疗尿毒症合并心功能不全患者透析相关性低血压的效果。方法选择本院透析过程中反复发生低血压的尿毒症合并心功能不全的患者20例,将其随机分成2组,每组20例,对照组常规血液透析过程中加50%葡萄糖注射液80ml静脉滴注,观察组在对照组基础上加用生脉注射液50ml静脉滴注,治疗8周,观察两组血压及平均动脉压变化。结果治疗过程中低血压发生率观察组低于对照组(P<0.05);治疗后观察组收缩压、平均动脉压均高于对照组(P<0.05);两组治疗后左心室射血分数(P<0.05)均高于治疗前,且治疗后LVEF观察组高于对照组(P<0.05)。结论生脉注射液可降低尿毒症合并心功能不患者透析相关性低血压发生率,明显地增加LVEF,提高了对透析的耐受性。

Objective To Investigate the therapeutic effect of shengmai injection in the treatment of patients with uremia combined with cardiac insufficiency hypotension correlation by dialysis.Methods 20 cases of uremia combined with cardiac insufficiency hypotension who had repeatedly dialysis related hypotension were randomly divided into theraty group and control group.Control group was dealt with 50% glucose injection; while theraty group was dealt with shengmai injection 50 ml.The shengmai injection 50 ml were given for 8 weeks continuously based on the routine treatment in patients of treatment group,then compared the treatment effects.Results The incidence of hypotension theraty group was low than that of control group during course treatment（P 0.01）; systolic blood pressure and mean arterial blood pressure of theraty group were higher than those of control group after treatment（P 0.05）; LVEF was higher after treatment than that before treatment in two groups,and LVEF increment in theraty group was higher than that of control group（P 0.05）.Conclusion Shengmai injection in treatment of patients with uremia combined with cardiac insufficiency hypotension correlation by dialysis can reduce incidence rate,significantly improve LVEF and raise dialyzed tolerance.