一起猪链球菌病暴发流行的流行病学及病原学研究

EPIDEMIOLOGIC AND PATHOGENIC STUDY ON AN OUTBREAK OF ACUTE STREPTOCOCCAL DISEASE IN PIGS

目的 :1998年 7～ 8月 ,华东地区猪群中暴发流行一种急性传染病 ,且通过皮损感染了处理病猪的人 ,发生多例病人。为查明该病原体的生物学特征与流行疾病的关系 ,进行了调查研究。方法 :通过流行病学调查 ,并对病死猪及死亡患者进行了病理检查和分离病原体的鉴定。结果 :该病具有起病急、病情重、病程短、病死率高等特点。起病多似感冒 ,临床症状为高热、四肢疼痛 ,有的出现呕吐、腹泻等 ;迅速发展为肌炎、筋膜炎、DIC、多脏器功能衰竭、休克 ,并多于 2～ 3d内死亡。 2 5例患者中 ,临床表现为中毒性休克综合征的 16例 ,链球菌性脑膜脑炎综合征的 9例 ,此二者的病死率分别为 81.2 5%和 11.11%。从猪和病人标本中分离的病原体 ,其形态、染色性、生物学特征均为一致。结论 :对从患者血中和病猪脏器中分离的病原进行鉴定证明 ,两者均为链球菌。

Objective:To study the relation between the biologic characteristics of pathogen and acute streptococcal epidemic disease which occurred in pigs and some people who dealed with sick pigs in Huadong area in July to August,1998.Methods:Epidemic investigation,pathological examination of pigs and patients, and isolation and identification of pathogen were performed.Results:The disease was characterized by acute onset, serious illness, short course and high death rate.Clinical features included high fever, fibromyositis, fascitis, DIC, multi-visceral organ failure, shock, and died in 2～3 days. Among 25 patients, there were 16 with streptococcal toxic shock-like syndrome (STSS) and 9 with streptococcal encephalomeningitis syndrome, the death rate of both were 81.25% and 11.11% respectively. Pathogenic bacteria isolated from diseased pigs and patients had the same characteristics in morphology, staining and biology.Conclusion:The pathogens isolated from blood of patients and pigs were identified as the same streptococci.