超声造影评估宫颈癌化疗疗效

Contrast-enhanced ultrasound in assessing the effect of chemotherapy on cervical cancer

目的探讨CEUS在宫颈癌化疗疗效评估中的应用价值。方法对42例接受化疗的宫颈癌患者于化疗前及化疗后2周行CEUS检查,应用时间-强度曲线分析病灶造影剂到达时间(AT)、达峰时间(TTP)和峰值强度(PI)。采用妇科检查结合MRI评价化疗疗效,比较不同疗效间CEUS检查结果的差异。结果 29例治疗有效,病灶造影剂AT及TTP较化疗前延长(P均<0.05),PI较化疗前下降(P>0.05);13例治疗无效,病灶造影剂AT及TTP较治疗前缩短(P均>0.05),而PI较治疗前明显增高(P<0.05)。结论应用CEUS技术检测宫颈癌化疗前后肿瘤血流灌注的变化可反映化疗疗效,为疗效评估提供可靠依据。

Objective To observe the value of CEUS in assessing the effect of chemotherapy on cervical cancer. Methods CEUS was performed before and 2 weeks after chemotherapy in 42 patients with cervical cancer. Time-intensity curves were analyzed to get arriving time （AT）, time to peak （TTP） and peak intensity （PI） of contrast media. CEUS results of patients with different chemotherapy efficacy assessed by gynaecology examines combined with MRI were compared. Resuits There were 29 cases with response to chemotherapy and 13 without response to chemotherapy. In patients with re sponse to chemotherapy, AT and TTP of contrast dramatically prolonged （P〈0.05）, while PI decreased （P〉0.05） after chemotherapy compared with those before chemotherapy. In patients with no response to chemotherapy, AT and TTP of contrast became shorter, while PI increased （P〈0.05） after chemotherapy. Conclusion Perfusion mode of cervical cancer assessed by CEUS can reflect therapeutic effect, which may provide reliable basis for evaluation of chemotherapy.