摘要
SUMO(Small ubiquitin-related modifier)化修饰是普遍存在于真核生物中的一种翻译后修饰,在很多细胞过程中发挥重要作用。文章阐述了拟南芥中SUMO底物的最新研究进展。首先介绍SUMO化修饰过程,SUMO底物的鉴定,包括鉴定方法的进展和鉴定成果。然后依据底物的亚细胞定位、生理功能和参与的生理生化过程对其进行分类和分析,以期更好地理解蛋白质SUMO化修饰方式在植物生长发育中的功能。
SUMO (Small ubiquitin-related modifier) modification, one of the essential posttranslational modifications in eukaryotes, plays an important role in various cellular processes. This review summarized the recent progresses on SUMO substrates in Arabidopsis. We firstly described the pathway of SUMO conjugation, and then focused on screening for SUMO substrates, including the methods of identification and SUMO substrates identified. Finally, we classified these sub- strates on the basis of their subcellular localization, functions, and biological processes. It is expected to provide the basis for better understanding the roles of sumoylation of proteins in plants.
出处
《遗传》
CAS
CSCD
北大核心
2013年第6期727-734,共8页
Hereditas(Beijing)
基金
国家自然科学基金项目(编号:30670189)资助
关键词
SUMO化修饰
底物鉴定
翻译后修饰
拟南芥
sumoylation
identification of targets
post-translational modification
Arabidopsis