FHIT和PCNA在膀胱尿路上皮癌中的表达及相关性

Expression and Relationship of FHIT and PCNA in Bladder Urinary Epithelial Cancer

目的:探讨脆性组氨酸三联体基因(FHIT)和细胞增殖核抗原(PCNA)蛋白在膀胱尿路上皮癌组织中的表达及相关性。方法:采用免疫组化法检测62例膀胱尿路上皮癌组织中FHIT和PCNA蛋白表达,采用Spearman统计学方法进行相关性分析。结果:FHIT蛋白在正常膀胱组织中的阳性率明显高于膀胱尿路上皮癌组织,而PCNA蛋白的表达状况则相反,FHIT蛋白表达与膀胱尿路上皮癌的临床分期、病理分级相关,膀胱尿路上皮癌中FHIT与PCNA表达状况经Spearman相关性分析显示呈负相关。结论:联合检测FHIT和PCNA,有助于提高对膀胱尿路上皮癌侵袭能力的评估。

Objective To explore expression and relationship of （fragile histidine triad FHIT） and （prolifer- ating cell nuclear antigen PCNA） protein in bladder urinary epithelial cancer. Methods FHIT protein and PC- NA protein expression were detected by immunohistochemical method in 62 patients with bladder urinary epithe- lial cancer. Results The positive rate of expression of FHIT in normal bladder tissues was higher than that in bladder urinary epithelial cancer, while the positive expression level of PCNA in normal bladder was lower than that of bladder urinary epithelial cancer. FHIT was negatively correlated with PCNA by Spearman analysis. Conclusion Combined detection of FHIT and PCNA may be helpful to evaluate infiltrative capability of blad- der urinary epithelial cancer.