雌激素受体β基因多态性与老年女性高血压的相关性

Association of estrogen receptorβ gene polymorphisms with hypertension in postmenopausal women

目的探讨雌激素受体β（ERβ）基因多态性与中国汉族绝经后女性高血压病之间的相关性。方法检测2009年9月至2010年10月武汉大学中南医院就诊的71例高血压汉族绝经后妇女及同期50例无高血压病的同龄女性的ERβrs944050和rs4986938的单核苷酸多态性，分析其与高血压病的关联性。结果ERβ的SNPrs944050和SNPrs4986938的等位基因A、G频率在高血压组和对照组分别为0．500、0．500、0．540、0．460；0．077、0．923、0．170、0．830。基因型频率分布符合HardyWeinberg平衡。SNPrs4986938，G／G与G／A＋A／A之间差异有统计学意义（P〈0．05）。而对于SNPrs944050，并未观察到其在基因型频率方面的差异（P〉0．05）。SNPrs4986938的等位基因A降低了高血压病发生的风险（OR=0．41，95％C／0．18—0．92）。结论在中国汉族绝经后妇女中，ERβ基因SNPrs4986938的单核苷酸多态性与高血压病相关。

Objective To explore the association between estrogen receptor β （ERβ） gene polymorphisms and hypertension in postmenopausal women. Methods The relationship of two polymorphisms （rs944050 and rs4986938） with hypertension was examined in 71 postmenopausal women with hypertension and 50 healthy age-matched controls. Results In hypertension and control groups, the ERβ allelie frequencies of A and G were 0. 500, 0. 500, 0. 540, 0. 460; 0. 077, 0. 923, 0. 170, 0. 830 respectively. The genotypic distributions of both polymorphisms stayed within Hardy-Weinberg equilibrium. For polymorphism rs4986938, statistical difference existed between the wild-type genotype and a combination of heterozygous and homozygous variant genotypes （ P 〈 0.05 ）. The variant allele A of rs4986938 in ERβ gene decreased the risk of hypertension （OR = 0.41, 95% CI 0. 18-0.92）. Conclusion The polymorphism rs4986938 in ERβ gene was associated with an elevated risk of hypertension in Chinese Han postmenopausal women.