哌仑西平对兔心肌梗死心率变异性、压力反射敏感性与心肌电生理特性的影响

Effect of Pirenzepine on Heart Rate Variability, Baroreflex Sensitivity and Cardiac Electrophysiologic Characteristics in Rabbits After Myocardial Infarction

【目的】观察哌仑西平对兔心肌梗死 (MI)后心率变异性 (HRV)、压力反射敏感性 (BRS)和心肌电生理特性的影响。【方法】 36只兔随机分为对照组、心肌梗死组和哌仑西平组 ,2周后测量HRV、BRS、心室有效不应期离散性 (VERP D)和室颤阈值 (VFT)。各指标间进行相关性分析。【结果】心肌梗死后HRV各指标和BRS明显降低 ,VERP D明显增加 ,VFT降低。哌仑西平明显增加心肌梗死后HRV各指标和BRS ,减小VERP D ,增加VFT。HRV、BRS与VERP D、VFT有明显的相关性。【结论】哌仑西平增加心肌梗死后迷走神经活性 ,增加心肌电稳定性。哌仑西平增加心脏迷走神经活性 ,可能是其抗心室颤动的机制之一。

Objective To study the influences of pirenzepine on heart rate variability, baroreflex sensitivity and cardiac electrophysiologic characteristics in rabbits after myocardial infarction. Methods Thirty-six rabbits were divided into three groups at random: the control group, the myocardial infarction group and the pirenzepine group. After two weeks, following parameters were measured: heart rate variability (HRV), baroreflex sensitivity(BRS), a dispersion of ventricular effective refractory period(VERP-D) and ventricular fibrillation threshold(VFT). Correlation was analyzed among these parameters. Results After myocardial infarction, HRV and BRS were decreased, VERP-D was increased, and VFT was decreased. In comparison with myocardial infarction group, HRV, BRS and VFT were increased and VERP-D was decreased in pirenzepine group. HRV and BRS had significantly correlation with VERP-D and VFT. Conclusion Pirenzepine has the effect of increasing parasympathetic activity and ventricular electric stability , so, it might prevent ventricular fibrillation after myocardial infarction.