绝经后妇女Lp(a)的变化及与其它血脂代谢指标的关系

Change of Lp(a) Level and the Relationship between Lp(a) and Lipid Profile in Postmenopausal Women

【目的】探讨心血管疾病的危险因子脂蛋白a[Lp(a) ]在绝经后的变化及与其它血脂代谢指标的关系。【方法】采用ELISA方法测定 76例绝经后妇女和 5 3例绝经前妇女的Lp(a)的水平 ,并同时测定血TC、TG、HDL、LDL、ApoA1、ApoB、ApoE的水平。【结果】Lp(a)的水平在绝经后的妇女中显著增加 (P <0 0 1) ,绝经后妇女血TC、TG、LDL、ApoB、ApoE的水平高于绝经前妇女 ;Lp(a)的水平与各脂代谢指标不相关 (P >0 0 5 )。【结论】绝经后妇女血Lp(a)的水平较绝经前升高且与各脂代谢指标不相关 ,提示绝经后心血管疾病的危险因子增加 ,而Lp(a)是绝经后妇女患心血管疾病的独立危险因子。

Objective To study the change of Lp(a) level and the relationship between Lp(a) and lipid profile in postmenopausal women. Method Lp(a) in 76 postmenopausal women and 53 premenopausal women were measured with ELISA, together with the level of TC,TG,HDL,LDL,ApoA 1,ApoB and ApoE. Result The level of Lp(a) was remarkably higher in postmenopausal women than in control group, the level of TC,TG,LDL,ApoB,ApoE of postmenopausal women were increased. No associations of serum Lp(a) with age,BMI,TC,TG,HDL,LDL,ApoA 1,ApoB and ApoE were found in pre- and postmenopausal women. Conclusion The risk factors for cardiovascular disease are increased in postmenopause, and Lp(a) is an independent risk factor for cardiovascular disease in postmenopausal women.