成体神经干细胞与微环境

Adult neural stem cells and the microenvironment

背景:成体神经干细胞广泛分布于中枢神经系统,它存在于特殊的微环境中,有自我更新和分化能力,可作为内源性干细胞来源来修复受损的神经组织。目的:归纳总结神经干细胞与微环境的研究与进展。方法:由第一作者检索PubMed(1989至2012年)数据库与中国期刊全文数据库(CNKI:2001至2012年),检索词分别为"神经干细胞;微环境;调控"和"neural stem cells;microenviroment;regulation"。结果与结论:阅读文题和摘要进行筛选,选择具有原创性,论点论据可靠且分析全面、密切相关的文章,排除重复性研究与以及质量较差文章,共检索到379篇英文文章,131篇中文文章,按纳入及排除标准筛选后,共纳入64篇文章。微环境中的各种组成成分如血管及内皮细胞、星形胶质细胞、室管膜细胞、细胞外基质与神经干细胞关系密切,在成体神经干细胞的生存、增殖、分化调控中均发挥重要作用。同时,成体神经干细胞的分化受基因调控。成体神经干细胞与微环境两者之间的研究将为神经组织的修复带来新的方向。

BACKGROUND：Adult neural stem cel s are widely distributed in the central nervous system, and have self-renewal and differentiation potential, which can be used as endogenous stem cel s to repair injured nerve tissues. OBJECTIVE：To summarize the research progress of neural stem cel s and the microenvironment. METHODS：The first author searched PubMed （1989/2012） and CNKI （2001/2012） using the key words of＂neural stem cel s;microenvironment;regulation＂in English and Chinese, respectively. RESULTS AND CONCLUSION：By screening title and abstract contents, papers with original, reliable and comprehensive analysis were selected, and repetitive research and poor quality articles were excluded. There were 379 English papers and 131 Chinese papers. Final y, only 64 papers were included in result analysis. Adult neural stem cel s are closely related to the major cel ular components of the microenviroment （vessels, endothelial cel s, astrocytes and ependymal cel s） and the extracel ular matrix in which they are embedded, playing an important role in the regulation of adult neural stem cel survival, proliferation, differentiation. At the same time, the differentiation of adult neural stem cel s is regulated by genes. It wil produce a new direction of nerve tissue repair between the study of adult neural stem cel s and the microenvironment.