透明质酸在骨组织工程研究中的应用现状

Application of hyaluronic acid in bone tissue engineering

背景:用组织工程学方法促进骨组织再生,是近年来骨缺损修复的研究热点。支架材料是骨组织工程研究的重要内容。目的:分析透明质酸作为骨组织工程支架材料的应用进展。方法:对CNKI、PubMed数据库进行文献检索,以"透明质酸,骨"为中文检索词、"hyaluronicacid,bone"为英文检索词。提取文献进行透明质酸作为骨组织工程支架材料的应用研究的分析。分析了透明质酸的物理特性,透明质酸在骨组织工程中的应用,以及相关文献的发表情况。结果与结论:透明质酸是一种重要的细胞外基质,透明质酸及其衍生物有优良的特性,是构建组织工程支架的优良材料,且可作为生长因子及细胞的输送载体。国家自然科学基金是资助透明质酸作为骨组织工程支架材料的应用的相关文献最多的基金,湖北中医学院、解放军总医院、广州中医药大学、华南理工大学发表相关文献较多。近年透明质酸在骨组织工程上的应用研究引起了越来越多的关注,但其临床研究较少。

BACKGROUND： Using tissue engineering method to promote bone tissue regeneration is a hot research point of bone defect repair in recent years, and scaffold materials are the important content for bone tissue engineering research. OBJECTIVE： To analyze the application progress of hyaluronic acid used as a tissue engineering scaffold material. METHODS： The CNKI database and PubMed database were searched with the key words of ＂hyaluronic acid, bone＂. The literatures about the analysis on the application of hyaluronic acid as the tissue engineering scaffold material were selected. The physical characteristics of hyaluronic acid and application of hyaluronic acid in bone tissue engineering were analyzed, as wel as the publishing of related literatures. RESULTS AND CONCLUSION： Hyaluronic acid is an important component of the extracel ular matrix, and hyaluronic acid and its derivatives have excel ent characteristics, which are the excel ent materials for building tissue engineering scaffolds, and can be used as carriers for growth factors and cel delivery. The National Natural Science Foundation of China is the foundation that supports the most literatures on the application of hyaluronic acid used as the tissue engineering scaffold materials. Hubei Col ege of Traditional Chinese Medicine, General Hospital of PLA, Guangzhou University of Chinese Medicine and South Chine University of Technology published most of the relevant literatures. In recent years, the application of hyaluronic acid in the bone tissue engineering has attracted more and more attention, but the research on its clinical application is rare.