医务人员接种甲型H1N1流感疫苗抗体水平的长期随访分析

Long term follow up of the antibody level of influenza A/H1N1 vaccine immunization in medical staffs

目的调查随访大兴安岭地区医务工作者注射甲型H1N1流感疫苗后不同时间抗体水平的动态变化规律。方法采用单纯随机抽样方法抽取内蒙古林业总医院45名甲型H1N1流感抗体阴性医务工作者为研究对象,接种国产甲型H1N1流感疫苗,接种时间为2009年10月28日-12月22日,随访统计接种后第1、2、3、27个月时的抗体滴度及阳转率。应用SPSS 16.0进行统计学处理,两组比较采用χ2检验及t检验。结果甲型H1N1流感疫苗在不同年龄组、性别间的免疫效果差异无统计学意义(P>0.05)。与第1个月抗体阳转率(95.56%)相比,随着免疫时间的推移,阳转率逐渐下降。与第1个月抗体滴度(265±92)相比,除第2个月(231±67)与其差异无统计学意义外(P=0.07),第3个月(183±88)及第27个月(46±38)抗体滴度均低于第1个月(P=0.03、P<0.01)。结论内蒙古林业总医院医务工作者接种甲型H1N1流感疫苗免疫效果好,持续时间长,随访27个月时仍然有44%的人群存在保护性抗体。

Objective To investigate the antibody levels of influenza A/HIN1 vaccine in medical staffs from Daxin-ganling Region, and its dynamic variation rule. Methods 45 medical staffs with negative influenza A/H1N1 antibody worked in Inner Mongolia Forestry General Hospital were selected randomly as research objects. All of them were inoc-ulated influenza A/H1N1 vaccine from October 28 to December 22, 2009. The antibody titer and positive conversion rates at 1, 2, 3, 27 months after inoculation were follow-up investigated. SPSS 16.0 software was used for statistical treatment, the t test and X^2 test were used for two groups comparison. Results The immune effects had no significantly different among the medical staffs with different age and sex. Compared with the positive conversion rate （95.56%） of the first month, as the immune time went on, the positive conversion rates reduced. Compared with the antibody titer （265±92） of the first month, the antibody titer of the second month （231±67） had no significant difference （P = 0.07）, the antibody titers of the third month （183±88） and the 27th month （46±38） had significant differences （P = 0.03 or P 〈 0.01 respectively）. Conclusion The protective immune antibody induced by A/H1N1 influenza vaccination can last till 27 month of immunization, with about 44% of health medical staffs having protective immune antibody titers.