摘要
目的 :探讨祛风湿方剂抗风湿作用的机制。方法 :采用大鼠佐剂性关节炎 (AA)作为类风湿性关节炎的病理模型 ,强的松作为阳性对照药。结果 :方剂大、中剂量能使AA大鼠腹腔巨噬细胞释放升高的过氧化氢(H2 O2 ) ,白细胞介素 1(IL 1)水平显著降低 (P <0 .0 5 ) ,作用强度与强的松相近。结论 :该方剂使AA大鼠升高的IL 1及H2 O2 的水平下降可能是其抗风湿的作用机制之一。
Objective: To study the mechanism of antiarthritis effects of Qufengshi Prescription. Methods: Adjuvant arthritis (AA)was applied as pathological model of rheumatoid arthritis and prednisone was used as positive control.Results:The Prescription at high and medium dosages significantly decreased the rising level of hydrogen peroxide and interleukin-1 in AA rats ( P <0.05),the potency being similar to prednisone. Conclusion: Qufengshi Prescription Could reduce the rising level of interleukin-1 and hydrogen peroxide in AA rats, which may be part of mechanism of the antiarthritis effect. [
出处
《中国中药杂志》
CSCD
北大核心
2000年第9期548-551,共4页
China Journal of Chinese Materia Medica
关键词
祛风湿方剂
佐剂性关节炎
过氧化氢
IL-1
Qufengshi Prescription
adjuvant arthritis
hydrogen peroxide
interleukin-1
