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肺癌患者组织中p15、p16纯合缺失

Homozygous deletion of p15. p16 genes in lung cancer
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摘要 目的探讨p15、p16基因在肺癌组织中纯合缺失情况。方法对59例肺癌组织和14例肺部良性组织,应用PCR法检测p15、p16基因纯合缺失情况。结果在肺癌组织中p15、p16基因改变频率分别为11.9%、23.8%。而在肺部良性组织中只有p16基因1例阳性。结论p16基因在肺癌组织中改变率相对较高;p15、p16基因在肺癌的研究中可能具有一定的价值。 Objective To assess the homozygous deletion of p15,p16 genes in lung cancer.Methods In 59 cases of lung cancer and 14 cases of benign respiratory diseases ,the homozygou dele-tion of p15 and p16 gene were detected. Results The frequency of homozygous deletion of p15.p16was 11. 9 %. 23. 8% respectively and only one case of benign disease showed p16 homozygous dele-tion. Conclusion Homozygous deletion of p16 is common in lung cancer and the two genes may bevaluable for the study on lung cancer.
出处 《临床内科杂志》 CAS 2000年第5期277-279,共3页 Journal of Clinical Internal Medicine
基金 湖北省"95"攻关项目!961P1801
关键词 肺癌 P15基因 P16基因 纯合缺失 Lung neoplasms p16 gene p15 gene
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