白细胞介素-5、可溶性白细胞介素-2受体及一氧化氮与哮喘发病的关系

Relationship between IL-5, sIL-2R, No and onset of asthma

目的探讨白细胞介素－5（IL－5）、可溶性白细胞介素－2受体（sIL－2R）、一氧化氮（NO）及嗜酸性粒细胞（EOS）在哮喘发病中的意义。方法对治疗前后的急性发作期、稳定期哮喘组及对照组血清IL－5、sIL－2R和NO水平及EOS计数进行了研究。结果哮喘急性发作组血清IL-5、sIL－2R、NO及EOS水平均明显高于哮喘缓解期组与对照组。哮喘发作期IL－5与EOS呈显著正相关。哮喘息性发作期组治疗后sIL－2R及NO水平较治疗前显著降低，IL－5与EOS水平下降但无统计学意义。结论血清IL－5、sIL－2R、NO及EOS水平升高，与哮喘发作密切相关。

Objective To evaluate the relationship between IL-5, slL-2R, NO and onset ofasthma. Methods The serum levels of IL-5, sIL-2R, NO and EOS count were determined in pa-tients at acute and stable stage before and after treatment, being compared with normal controls.Results The levels of IL-5,slL-2R. NO and EOS in patients at acute stage were significantly higherthan those in patients at stable stage and controls. At acute stage. IL-5 was positively related to EOS.The serum levels of sIL-2R and NO in patients at acute stage obviously decreased after treatment, butthe level of IL-5 and EOS didn'reach the significant decline. Conclusion Increase of IL-5, sIL-2R.NO and EOS levels are closelv related to onset of asthma.