哮喘患者气道阻力变化对中枢驱动的影响

Changes of airway resistance and central drive in patients with asthma

目的了解哮喘患者气道阻力的变化对中枢驱动的影响。方法对13名正常人和21例哮喘患者作气道反应性测定，于激发试验前后分别测定吸气初0．1s时口腔阻断压（P_(0.1)），其中10例哮喘患者激发试验后吸入喘乐宁，测定FEV_1及P_(0.1)。结果正常人9名（9／13）、哮喘患者19例（19／21例）组胺激发试验后P_(0.1)较激发前显著升高．两组P_(0.1)且升高人数的百分比比较差异无显著性，哮喘患者激发后FEV_1％与P_(0.1)呈负相关（r＝－0．4576，P＜0．05），10例哮喘患者激发后吸入喘乐宁，FEV_1较激发后显著上升,P_(0.1)则显著下降。结论组胺诱导哮喘患者支气管收缩时，FEV_1下降，P_(0.1)上升，二者呈负相关，吸入支气管舒张剂后，FEV_1上升，P_(0.1)下降，表明中枢驱动受气道阻力的影响。

Objective To study the effect of change in airway resistance on central drive in pa-tients with asthma. Methods Bronchial provocation tests were done in 13 normal subjects and 21 pa-tients with asthma. The mouth occlusion pressures at 0. 1 second at the beginning of inspiration(P_0.1 ) were measured before and after provocation. while FEV_1 and P_0. 1 were measured in 10 patientswho inhaled Artrovent after provocation. Results P_0.1 increased significantly in 9 normal subjects(9/13) and 19 patients (19/21 ) after provocation test. FEV_1 correlated negatively with P_0. 1 in pa-tients after provocation test (r = - 0. 4576 . P <0. 05 ). In 10 patients who inhaled Artrovent afterprovocation test, FEV_1 and P_0. 1 significantly increased and decreased, respectively. Conclusion Cen-tral drive may be influenced by airway resistance.