宫颈液基细胞学与巴氏涂片在宫颈病变检查中的应用研究

Clinical study of thin-prep cytology test and Pap smear in the examination of cervical lesions

目的:探讨与分析宫颈液基细胞学(TCT)与巴氏涂片在宫颈病变检查中的应用价值。方法:选择2009年3月～2011年3月来我院妇科予以常规细胞学筛查的255例患者为研究对象,其中130例患者予以宫颈液基细胞学检查作为TCT组,125例患者予以巴氏涂片检查作为对照组,比较两组诊断差异。结果:TCT组的灵敏度、特异度、诊断符合率分别为92.59%、81.63%、88.46%,而对照组则为77.03%、49.02%、65.60%,两组经比较均P<0.01。TCT组检查CIN的灵敏度、特异度、诊断符合率分别为81.25%、92.68%、88.46%,而对照组则为42.86%、76.32%、63.20%,两组经比较均P<0.01。TCT组检查SCC的灵敏度、特异度、诊断符合率分别为100%、100%、100%,而对照组则为50%、98.37%、97.60%,两组经比较均P>0.05。结论:TCT检查宫颈病变优于巴氏涂片检查,是筛查宫颈病变的最有效方法,值得临床推广运用。

Objectives： To investigate and analyze the application value of thin -prep cytology test and Pap smear in the examination of cervical lesions. Methods： 255 patients who came to our hospital from March 2009 to March 2011 were divided into two groups： TCT group （130 patients detected by thin -prep cytology test） and control group （125 patients detected by Pap smears）. Their diagnoses were compared. Results： In TCT group, the sensitivity, specificity, diagnostic accordance rates were 92. 59%, 81.63%, 88. 46%, respectively, while in the control group they were 77.03%, 49.02%, 65.60%, respectively. CIN sensitivity, specificity, diagnostic accordance rates of TCT group were 81.25%, 92. 68%, 88.46%, respectively, while in the control group they were 42. 86%, 76. 32%, 63. 20%, respectively. SCC sensitivity, specificity, diagnostic accordance rates of TCT group were 100%, 100%, 100%, respectively, while in the control group they were 50%, 98.37%, 97.60%, respectively. Conclusion： TCT examination of cervical lesions is better than Pap smear. It is the most effective method of screening for cervical lesions, and is worthy of clinical application.