静脉滴注丙种球蛋白联合低分子肝素联合治疗42例复发性流产临床疗效观察

Intravenous infusion of gamma globulin combined with low molecular heparin in treatment of recurrent miscarriage

目的:探讨静脉滴注丙种球蛋白联合低分子肝素对于复发性流产孕妇的临床疗效及安全性。方法:将本院收治的84例抗心磷脂抗体(ACA)阳性的复发性流产患者随机分为实验组和对照组,实验组患者给予静脉滴注丙种球蛋白联合低分子肝素治疗,对照组患者给予黄体酮联合HCG的传统保胎治疗,比较两组患者保胎成功率及不良反应的发生情况。结果:实验组保胎成功率81.0%,对照组保胎成功率31.0%,实验组保胎成功率显著高于对照组(P<0.05)。两组患者均无严重不良反应发生。结论:对于ACA阳性的复发性流产患者,静脉滴注丙种球蛋白联合低分子肝素疗效显著且安全性高,值得临床推广应用。

Objectives： To investigate clinical efficacy and safety of intravenous infusion of gamma globulin and LMWH in treating recurrent miscarriage. Methods： 84 recurrent miscarriage patients of anti -cardiolipin antibodies （ACA） -positive were randomly divided into experimental group and control group. Patients in the experimental group were treated with intravenous infusion of gamma globulin combing low - molecular - weight heparin while the control group was given the traditional miscarriage treatment such as progesterone combined with HCG. Tocolytic. The success rate and the incidence of adverse effect in the two groups were compared. Results： Tocolysis rate of the experimental group was 81.0%. the control group 31.0%, which was much lower （ p 〈 0.05 ）. Patients in the two groups had no serious adverse reactions. Conclusions ： Intravenous infusion of gamma globulin and LMWH treatment can be used among ACA positive patients with recurrent miscarriage after overall considering its efficacy and safety.