精子优选方法对人工授精治疗结局的影响

Influence of sperm selection on the results of artificial insemination treatment

目的:回顾分析不同精子优选方法对人工授精治疗结局是否有影响。方法:选择2010年1月～2011年12月在本中心行AIH治疗的504对夫妇共732个周期为研究对象,按精子优选处理方法进行分组:上游法314个周期,密度梯度离心法418个周期,比较两种精子优选方法行人工授精在临床妊振率、流产率和子代性别的差异。结果:上游法和密度梯度离心法的周期妊娠率分别为8.6%、6.7%,流产率分别为25.9%、17.9%,差异无统计学意义(P>0.05);两种方法处理后行人工授精的婴儿性别比例比较差异无统计学意义(P>0.05)。结论:上游法和密度梯度离心法应用在夫精人工授精中临床妊娠率、流产率无差异,精子优选方法对子代性别无影响。

Objectives： To study different pregnancy rates of intrauterine insemination （IUI） achieved by different optimized high -quality sperm selection. Methods： Data from Jan 2010 to Dee 2011, in which 504 infertile couples who underwent 732 IUI cycles in our reproductive medicine center, were retrospectively analyzed. These treatment cycles were divided into two groups： swim -up 314 cycles and pure sperm density gradient centrifugation 418 cycles. Clinical pregnancy and abortion rate and offspring gender differences were compared. Results： In two groups, the pregnancy rates were 8.6% and 6.7% , with no statistically significant difference （ P 〉 0. 05 ）, the abortion rates were 25.9% and 17.9%, with no statistically significant difference （ P 〉 0.05 ） , and offspring gender differences were also no statistically significant difference （ P 〉 0. 05 ）. Conclusion： The clinical pregnancy and abortion rate had no difference between swim - up group and pure Sperm density gradient eentrifugation group for separating high - quality sperm. It has also no predictive value for babies＇ gender.