息县人民医院妇产科手术患者围术期预防性应用抗菌药物分析

Analysis of Perioperative Use of Prophylactic Antibiotics for Patients Undergoing Obstetric and Gynecological Operation in Xixian People’s Hospital

目的:分析我院妇产科手术患者围术期预防性应用抗菌药物的现状与合理性,为促进临床合理用药提供科学依据。方法:以随机抽样法抽取2012年1—12月我院妇产科出院归档的手术病历232份,统计分析我院妇产科手术患者围术期预防性应用抗菌药物情况,并评价其合理性。结果:232份手术病历中,使用的抗菌药物涉及8大类24个品种;头孢菌素类使用率最高,其次为硝基咪唑类、青霉素类、头霉素类、林可酰胺类;其中单一用药146例、二联用药84例、三联用药2例。抗菌药物存在不合理使用情况,主要表现为给药时间不合理、持续用药时间过长、联合用药不合理、用药剂量偏大、溶剂选择及药物浓度配制不当等。结论:我院妇产科手术患者预防性应用抗菌药物存在问题较多,有待进一步规范,应加强对抗菌药物合理使用的培训、监督、检查及规范化管理,以促进临床抗菌药物的合理使用。

OBJECTIVE： To analyze the status quo and rationality of perioperative use of antibiotics in patients undergoing obstetric and gynecological operation in our hospital so as to provide scientific basis for clinical rational use of drugs. METHODS ： A total of 232 filed medical records of patients undergoing obstetric and gynecological operation in our hospital discharged from our hospital during Jan. -Dec. period of 2012 were statistically analyzed with regard to perioperative use of antibiotics and evaluated regarding the rationality of antibiotic use. RESULTS： In the 232 cases, the use of antibiotics totalled 8 categories and 24 kinds, with cephalosporins used mostly frequently, followed by nitroimidazoles, penicillins, cephamycins and lincomycins. 146 received single drug, 84 received two drugs in combination, and 2 received three drugs in combination. The non-irrational antibiotic use mainly manifested as irrational in administration time, prolonged duration of drug administration, irrational in drug combination, overdosing, improper in choice of solvents or improper in dispensing concentration etc. CONCLUSION： The perioperative use of antibiotics in patients undergoing obstetric and gynecological operation in our hospital has many problems that remain to be standardized. It is important to intensify the training, supervision, inspection, and standardized management on the rational use of antibiotics so as to promote clinical rational use of antibiotics.