多巴酚丁胺对犬内毒素休克的影响

Effects of dobutamine in dog with endotoxin shock

目的 研究多巴酚丁胺在内毒素休克时所起的作用。方法 选用成年杂种犬 12只 ,随机分成 2组 ,第一组 (n =6 )用 2 5 0 μg/kg持续静注内毒素 30分钟。第二组 (n =6 )除用同样的方法静注内毒素外 ,从第 12 0min起按 10 μg·kg-1·min-1持续输注多巴酚丁胺至实验结束。两组动物从开始到结束 ,每隔半小时测定一次MAP、CVP、MPAP、PAWP、HR和CO ,并计算出SI,SVRIPVRI,DO2 ,VO2 和O2 ER。结果 与对照组相比 ,治疗组能使内毒素休克犬的心输出量 (CO)、氧输送 (DO2 )、氧耗量 (VO2 )及肠系膜上动脉的血流量明显增加 (P <0 0 5～ 0 0 1)。结论 多巴酚丁胺可显著改善内毒素休克的血液动力学及缺血脏器的血供 ,氧供对感染性休克治疗有益。

Objective To investigate the effects of dobutamine at a rate of 10 μg·kg -1 ·min -1 on hemodynamics,systemic and regional oxygen uptake and delivery in endotoxin shock dogs.Methods Two groups of normal adult dogs were selected at random. Group 1( n =6) received an infusion (T=0 min) of 250 μg/kg Escherichia coli endotoxin and normal saline for resuscitation.Group 2( n =6) received the same infusion of endotoxin and resuscitation as group 1,but an infusion of dobutamine (10 μg·kg -1 ·min -1 )was begun at T=120 mins,and continued throughout the experiments.MAP,CVP,MPAP,PAWP,HR and CO values were measured,as well as the SI,SVRI,PVRI,DO 2,VO 2 and O 2ER values were calculated.Results In the Dobutamine-treated group,cardiac output,flux flow of superior mesenteric artery,systemic and regional DO 2,VO 2 were higher than those in the control group.Conclusion Dobutamine provided hemodynamic support and increased flux flow of superior mesenteric artery in endotoxin shock dogs,thereby increased the systemic and regional DO 2 and VO 2 levels.