静脉地尔硫治疗老年人快速心室率房颤、房扑和室上速的临床观察

A clinical study of atrial fibrillation, atrial flutter or supraventricular tachycardia of elderly patients treated by intravenous Diltiazem

目的 观察静脉地尔硫艹卓 对老年人快速心室率的房颤、房扑及室上速的疗效与安全性。方法 1 5例患者 (7例房颤、3例房扑、5例室上速 )静脉注射地尔硫艹卓 1 0～ 1 5mg,有反应者继以 1 0～ 1 5mg/ h浓度持续静点 6～ 1 2 h。结果 用药后心室率比用药前基础心率减少 >2 0 % ;转复为窦性心律或心室率 <1 0 0次 / min为治疗有反应 ,本组 1 5例患者 1 2例 (80 % )有反应 ;用药后心室率下降最大效应时间 1 1 min,心室率下降幅度 42± 1 6次 / min。结论 地尔硫艹卓 能安全地应用于快速心室率的房颤或房扑及室上速的老年人 ,并在大多数病人能迅速有效地达到心率的控制和中止室上速的发作 ,而且不会引起或加重心功能障碍。

To investigate clinical efficacy and safety of intravenous diltiazem in elderly patients with atrial fibrillation, atrial flutter or supraventricular tachycardia.Methods fifteen cases received an intravenous bolus dose of Diltiazem of 10～15 mg, followed by infusion of 10～15 mg/h for 6～12 hours.Results 80% of patients(12 of 15) responded to the Diltiazem with a >20% reduction in heart rate conversion to sinus rhythm or a heart Rate <100 beats/min.The maximum peak time of therapeutic effects was 11 min, The mean decline of ventricular rate was 42±16 beats/min.Conclusions Intravenous Diltiazem is rapid, effective and safe in controlling rapid ventricular rate of atrial fibrillation or atrial flutter and converting supraventricular tachycardia to sinus rhythm without initiating or aggravating cardiac dysfunction in the elderly patients.