大鼠脑缺血/再灌流中钙与神经元凋亡关系的研究

An investigation of the relationship of calcium overload and neuronal apoptosis in cerebral ischemia/reperfusion injury rats model

目的 观察钙超载与神经元凋亡的关系。方法 采用大鼠全脑缺血模型 ,观察脑缺血 /再灌流后突触体游离钙、神经元凋亡的变化。结果 脑缺血 /再灌流可以导致突触体游离钙增加及神经元的凋亡 ,脑缺血 /再灌流神经元内游离钙浓度的变化与神经元凋亡的变化是一致的。结论 脑缺血 /再灌流诱导钙超载参与了神经元凋亡。

To explore the relation between calcium overload induced by cerebral ischemia/reperfusion and neuronal apoptosis.Methods After the ischemia/reperfusion model was established in male Wistar rat, the changes of intraneuronal free calcium content and neuronal apoptosis were observed.Results cerebral ischemia/reperfusion could result in calcium overload and incerase of neuronal apoptosis.The change of intracellular free calcium content was in accordance with that of neuronal apoptosis induced by cerebral ischemia/reperfusion injury.Conclusions The calcium overload was involved in neuronal apoptosis induced by cerebral ischemia/reperfusion.