武汉地区汉族人AT1受体基因A1166C与原发性高血压的关系

Relationship between the Angiotensin Ⅱ Type 1 Receptor Gene A1166C Polymorphism and Human Primary Hypertension in the Han People of Wuhan

血管紧张素 1型 (AT1)受体基因突变体 A116 6 C(碱基 A被 C取代 )可能与原发性高血压的发生有关 ,但目前的研究结果并不一致。利用对靶基因的 PCR扩增片段进行酶切的方法对武汉地区 10 3例汉族人 AT1受体基因多态性 (A116 6 C)与原发性高血压发生的关系进行了分析 ,发现正常人和原发性高血压患者两组间 A116 6 C基因型频率分别为 40 %和 6 2 % (χ2 =4.95 ,P<0 .0 5 )。初步结果表明 ,被检测者中 A116 6 C在原发性高血压患者和正常人两组间有显著性差异。

By using polymerase chain reaction followed by restriction analysis on the targeting gene, the relationship between angiotensin Ⅱ type 1 receptor gene A1166C polymorphism and human primary hypertension in 103 Han People of Wuhan was analyzed. It was found that frequency of A1166C in the healthy population and in the patients with primary hypertension was 40 % and 62 % respectively (χ 2=4.95, P <0.05). It was suggested that polymorphism of the AT1 receptor gene might be associated with the development of primary hypertension.