儿宝颗粒剂对幼鼠厌食动物模型下丘脑、垂体、胃窦及血浆中β-内啡肽含量的影响

The Influence of Erbao Granule on the Hypothalamus,Hypophysis,Sinus Ventriculi and the Content of β-endorphin in the Plasma of Infantile Animal Pattern

模拟小儿厌食症主要病因制作幼龄大鼠动物模型 ,用临床有效运脾复方儿宝颗粒剂治疗 ,测定大鼠下丘脑、垂体、胃窦及血浆中 β -内啡肽含量 ,观察运脾复方对该模型中枢和外周 β -内啡肽的调节作用。结果显示模型动物与正常对照动物相比 ,血浆和胃窦 β -内啡肽含量明显减少 (P<0 .0 5) ,而下丘脑、垂体含量变化不大 ;大小剂量治疗组血浆 β -内啡肽恢复正常 ,大剂量组下丘脑、垂体和胃窦 β -内啡肽含量增加 ,显著高于正常组 (P <0 .0 0 1)。

Simulate main cause of the child apositia to build the infantile rat model, treat with the clinically effective compound Erbao granule, determine the hypothalamus, hypophysis, sinus ventriculi and the content of β-endorphin in the blood plasma of the rat, then observe the adjusting of the compound prescription on the pattern's central and peripheral β-endorphin. The result showed that, comparing the pattern animal with the normal animal, the contents of β-endorphin in the plasma and sinus ventriculi decreased obviously (P<0.05), while the contents didn't change much in the hypothalamus and hypophysis. Both in the large and small dosage treatment groups the β-endorphin of plasma recovered to normal. In the large dosage group, the content of β-endorphin in the hypothalamus, hypophysis and sinus ventriculi increased, obviously higher than in the normal group(P<0.001).