辛伐他汀对高脂饲喂家兔血脂的影响

Effect of simvastatin on hypercholesterolemia in cholesterol-fed rabbits

目的 :验证HMG CoA还原酶抑制剂辛伐他汀的降血脂作用。方法 :用含 3 %胆固醇饲料饲喂家兔 ,造成高脂血症模型。考察灌胃给药对血脂的影响。结果 :口服辛伐他汀可剂量依赖性地抑制血清总胆固醇 (TC)、甘油三酯(TG)的升高 ,对TC作用显著 ,TG有轻微降低 ,对高密度脂蛋白 (HDL C)有升高趋势 ,肝脏TC亦显著降低。降血脂作用与等剂量阳性对照药舒降之比较差异不显著。结论 :国产辛伐他汀对血脂升高具有预防作用。

OBJECTIVE:To verify the preventive effects of simvastatin,an inhibitors of HMGCoA reductase,on hypercholesterolemia in cholesterol-fed rabbits.METHOD:A 3% cholesterol diet was selected for the induction of hypercholesterolemia in rabbits.Each drug was adminstered orally.The lipid concentrations were determined by enzymatic method and chemical assay kit after 0,4 and 8 weeks of the treatment.RESULTS:Simvastatin was found to inhibit serum cholesterol(TC) and triacylglycerol(TG) levels from increasing dosedependently.It reduced the total cholesterol levels in serum and liver markedly,slightly reduced the triacylglycerol levels and slightly elevated the HDL cholesterol.The suppressing effects of 5mg/kg simvastatin on total cholesterol and triacylglycerol levels were found to be almost equal to that of 5mg/kg ZOCOR(simvastatin,MSD).CONCLUSION:Simvastatin(made in China) has cholesterollowering effects.