利培酮单用与合并加兰他敏对精神分裂症患者认知功能的影响

Comparison of the influence of risperidone and risperidone with galantamine on cognition in schizophrenic patients

目的:探讨加兰他敏对精神分裂症患者的认知功能是否有改善作用。方法:随机入组精神分裂症患者分为单用利培酮治疗组(单用药组,入组40例,完成30例)和利培酮合并加兰他敏治疗组(合用药组,入组40例,完成34例),在治疗前及治疗8周后分别进行威斯康星卡片分类测验(WCST)、Stroop色词测验、定步调听觉连续加法测验(PASAT)和范畴流利测验及阳性与阴性症状量表(PANSS)的评定。结果:与治疗前比较,两组PANSS评分均有显著改善(t=4.43～10.84,P均<0.01);两组间比较,单用药组PANSS评分阳性症状分量表的减分率高于合用药组(P=0.03)。两组治疗前后认知功能比较,单用药组Stroop色词测验中第3项色词测验治疗后的成绩显著好于治疗前(t=-3.47,P=0.00),但合用药组并未显示出这种差异(t=-1.32,P=0.20);其他各项认知测定两组治疗前后的改善均不明显,两组间比较,差异亦无统计学意义。结论:本研究未发现利培酮合并加兰他敏治疗能有效改善精神分裂症患者的认知功能。

Objective：To explore if galantamine can improve the cognition of patients with schizophrenia. Method：Patients were divided into 2 groups randomly,one was treated with risperidone （ single drug group,40 participants enrolled,30 patients finished the study） ,the other was adjunctive with galantamine （ drug adjunctive group,40 participants enrolled,34 patients finished the study ） . Wisconsin card sorting test （ WCST） ,Stroop color word test,paced auditory serial addition test （ PASAT） and ctegory fuency test were performed before treatment and 8 weeks after treatment. Positive and negative symptom scale （ PANSS） was also evaluated. Results：The score of PANSS was declined obviously in both groups （ t = 4. 43 ～ 10. 84,all P 0. 01） compared with the score evaluated before the treatment. The reduction of the score of positive symptom was more obvious in the single drug group （ P = 0. 03） . As to the comparison of the cognitive function,patients in single drug group improved greatly after treatment on the third test of the Stroop color word test （ t = - 3. 47, P = 0. 00） ; but this difference was not found in the drug adjunctive group（ t = - 1. 32,P = 0. 20） . The remaining cognitive tests were not improved greatly after the treatment in both groups. There were no statistically significant differences between two groups. Conclusion：Risperidone combining galantamine can not effectively improve the cognitive function of the patients with schizophrenia in this study.