宫颈注射天花粉蛋白治疗输卵管妊娠

Clinical Observation of the Effect Intracervical and Intramuscular Injection of Trichosanthin on Tubal Pregnancy

目的通过比较天花粉蛋白宫颈注射和肌肉注射的疗效和副反应 ,探讨宫颈注射天花粉蛋白治疗输卵管妊娠的临床价值。 方法对输卵管妊娠患者 1 8例行天花粉蛋白宫颈注射和 2 0例行肌肉注射 ,通过 2～ 3d复查尿hCG定量、B超监测盆腔包块大小变化 ,了解临床疗效。通过用药后患者头痛、咽痛、四肢酸痛及发热发生率和程度评价两种用药方法的副反应发生和严重程度。 结果两组患者年龄和一般资料无显著性差异 ,肌肉注射组和宫颈注射组治愈率分别达 90 %与 94% ,无显著性差异。宫颈注射组的副反应轻于肌肉注射组 ,尤其在体温升高及持续时间上 ,有显著性差异 (P <0 .0 5 )。 结论天花粉蛋白治疗输卵管妊娠总有效率达 92 % ,宫颈注射与肌肉注射效果相似 ,而全身副反应前者显著较轻。

Objective To evaluate Trichosanthin(TCS) in treating ectopic pregnancy by comparing to clinical efficacy and side effects between the intramuscular and intracervical adiministration group. Methods TCS was given to the patients by either the intracervical or the intramuscular route. Compare the clinical results. Results There was a 90%cure rate in the intramuscular injection group and a 94% cure rate in the intracervical injection group. Side effects were slighter in the intracervical injection group than intramuscular injection, especially in fever and its sustained time (P<0.05) 。 Conclusions The clinical efficacy was consistent in two groups but the side effects of the intra-cervical group were slighter.