急性冠脉综合征患者ADAMTS-1水平及其意义

A disintegrin-like and metalloproteinase-1 with thrombospondin type 1 motifs in acute coronary syndrome patients

目的:检测急性冠脉综合征(ACS)患者外周血含Ⅰ型血小板结合蛋白基序(TSP)的解聚蛋白样金属蛋白酶-1(ADAMTS-1)水平,探讨其在ACS患者中的临床价值。方法:选择84例急性ST段抬高心肌梗死(STEMI)患者、41例急性非ST段抬高心肌梗死(NSTEMI)患者、65例不稳定性心绞痛(UAP)患者、30例稳定性心绞痛(SAP)患者、对照组38例,采用ELISA法检测血浆ADAMTS-1水平。结果:UAP组血浆ADAMTS-1水平显著高于对照组(P<0.05),STEMI组与NSTEMI组血浆ADAMTS-1水平高于对照组,但差别无统计学意义。急性心肌梗死组在入院第3d血浆ADAMTS-1水平达到峰值;血浆ADAMTS-1水平与hsCRP、TIMI评分均正相关(均P<0.05)。结论:ACS患者血浆ADAMTS-1水平升高,血浆ADAMTS-1水平可能用来预测ACS患者预后。

Objective：To detect a disintegrin-like and metalloproteinase-1 with thrombospondin type 1 motifs （ADAMTS-1）in acute coronary syndrome （ACS）patients.Methods：In the study 84 ST elevated myocardial in- farction （STEMI）patients,41 non ST elevated myocardial infarction （NSTEMI）patients,65 unstable angina pec- toris（UAP）patients,30 stable angina pcctoris（SAP）patients,and 38 controls were included.ELISA was used to measure plasma ADAMTS-1.Results：PIasma ADAMTS-1 in STEMI group,NSTEMI group,UAP group,SAP group and control group were 53.73±60.01ng/ml,51.02±44.21ng/ml,64.19±56.64ng/ml,42.40±37.30ng/ml,34.98± 27.21 ng/ml, respectively.UAP group elevated significantly （P〈0.05） than control group.ADAMTS- 1 expressed high- er in STEMI group and NSTEMI group compared with control group （P〉0.05）.Plasma ADAMTS-1 peaked on the 3rd admission day in STEMI group and NSTEMI group.Plasma ADAMTS-1 had positive relations with hsCRP and TIMI scales（both P〈0.05）.Conclusion：Plasma ADAMTS-1 level is higher in ACS patients.h prob- ably can predict the prognosis for ACS patients.