血清IV型胶原诊断肝纤维化的价值

Clinical Significance of Serum Type IV Collagen Assay for the Diagnosis of Hepatic Fibrosis

目的探讨血清IV型胶原测定在诊断肝纤维化中的应用价值。 方法用ELISA法测定 2 0 9例各型病毒性肝炎患者及 5 3例健康体检者血清IV型胶原的水平。 结果血清IV型胶原水平在慢性肝炎中度患者明显升高 ,以慢性肝炎重度和肝硬化患者最高 ,三组患者与其他组比较差异有显著性 (P <0 .0 1 ) ,其升高程度与肝纤维化程度及肝病的严重程度呈正相关。 结论血清IV型胶原测定可以作为反映慢性肝病纤维化严重程度和预后的指标。

Objective To study the clinical significance of serum type IV collagen(IV-C)levels for the diagnosis of hepatic fibrosis. Methods Serum levels of IV-C were measured in 209 patients with viral hepatitis and 53 healthy persons by ELISA. Results Compared with the normal group, the serum IV-C level was significantly increased in patients with chronic moderate hepatitis and was the highest in patients with chronic severe hepatitis and hepatic cirrhosis(P<0.01). There was no significant difference in the serum IV-C level among acute viral hepatitis, chronic mild hepatitis and controls (P>0.05). There was significant difference in the serum IV-C level in patients with hepatic cirrhosis by Child-Pugh grading(P<0.01). The serum IV-C level was positively correlated with the degree of hepatic fibrosis and the severity of hepatic diseases.Conclusion The measurement of serum IV-C may be useful for assessment of the degree of hepatic fibrosis and prognosis of chronic hepatitis.