血清α1-抗胰蛋白酶、胆碱酯酶及甲胎蛋白联合检测在肝癌诊断中的临床意义

THE DIAGNOSIS VALUE OF COMBINED DETECTION OF SERUM AL-AT,CHE AND AFP IN LIVER CANCE

目的探讨血清α1-抗胰蛋白酶(α1-AT),胆碱酯酶(CHE)和甲胎蛋白(AFP)检测在肝癌诊断中的临床意义。方法随机筛选肝癌患者、良性肝病患者及健康体检者各45例,分别检测其血清α1-AT,CHE及AFP含量,统计分析各组间结果差异,并比较三种指标单独或联合检测对肝癌诊断的敏感性和特异性。结果血清α1-AT,CHE及AFP含量在肝癌患者组明显高于良性肝病患者组及健康体检组,差异有统计学意义(P<0.05);对肝癌的诊断方面,单项检测αl-AT、CHE及AFP的敏感性分别为87%、89%和82%,特异性分别为74%、80%和90%;三项联合检测的敏感性为93%,特异性为70%。结论三项联合检测提高了肝癌诊断的敏感性,有利于肝癌的早期诊断,降低了对肝癌的漏诊。

Objective To investigate the clinical significance of combined detection of serum al - antitripsien （αl- AT）,cholienesterase （CHE） and alpha- fetoprotein （AFP） for the diagnosis of liver cancer. Methods The levels of serum αl - AT,CHE and AFP were detected in 45 cases of liver cancer, 45 cases of benign liver disease and 45 normal controls, and the differences were analyzed among three groups. The sensitivity and specificity of the three indicators （alone or combined） were also evaluated for the diagnosis of liver cancer. Results The levels of serum al - AT,CHE and AFP in liver cancer group were significant higher than that in the benign liver disease group and normal control group （P〈0.05）. The detection sensitivity of αl - AT,CHE and AFP in liver cancer diagnosis were 87%, 89% and 82%, respectively, and the speci- ficity were 74%, 80% and 90%, respectively. The sensitivity and specificity of joint detection of αl - AT, CHE and AFP were 93% and 70%, respectively. Conclusion Joint detection of the three indicators foi- the diagnosis of liver cancer can improve the diagnostic sensitivity, which will be conductive to improving the early diagnosis and reducing the misdiagnosis.