糖皮质激素对支原体肺炎患儿T淋巴细胞亚群的影响

CHANGES OF IMMUNE FUNCTION IN CHILDREN WITH MYCOPLASMAL PNEUMONIAAND IN THE ASSISTANCE TREATMENT OF GLUCOCORTICOID

目的观察小剂量糖皮质激素辅助治疗小儿支原体肺炎(MPP)对免疫功能的影响,以期为MPP的治疗提供理论依据。方法将420例MPP患儿随机分为实验组和对照组各210例,二组均给予阿奇霉素进行治疗,其中实验组在此基础上给予小剂量糖皮质激素进行治疗。结果实验组痊愈比例明显高于对照组,而显效率明显低于对照组,差异有统计学意义(P<0.01),实验组CD3和CD4∕CD8水平明显高于对照组,而CD8明显低于对照组,差异均有统计学意义(P<0.01)。结论小剂量皮质激素辅助治疗小儿MPP,可有调节MPP紊乱的免疫功能。

Objective To observe the effect of low dose glucocorticoid on immune function in the assistance treatment of children with mycoplasmal pneumoniaand（mpp） , so as to provide theoretical basis for the treatment of MPP. Methods A total of 420 children with MPP were randomly divided into experimental group and control group with 210 cases in each group, all patients were given azithromycin treatment, on the basis of the administration the experimental group were given low doses of glucocorticoid for treatment. Results The proportion of recuperation were signifiqantly higher in the experimental group than those in control group, and significant efficiency was significantly lower than the control group, the difference was significant （P〈0.01）. The levels of CD3 and CD4 / CD8 were significantly higher in the experimental group than those in the control group, but CD8 was significantly lower than the control group, the differ- ences were obvious statistical significance （P〈0.01）. Conclusion low dose adjunctive corticosteroid ther- apy in pediatric MPP, can regulate MPP disorder on immune function.