阿托伐他汀治疗冠心病心绞痛60例临床效果观察

EFFECT OF ATORVASTATIN IN TREATMENT OF CORONARY HEART DISEASE ANGINA PECTORIS

目的探讨阿托伐他汀用于治疗冠心病所致的心绞痛的临床效果。方法选取2011年1月—2012年12月因心绞痛前来本院就诊的120例患者为研究对象,对患者进行随机分组,分别为观察组及对照组,每组各60例,其中观察组采用阿托伐他汀进行治疗,对照组采用硝酸异山梨醇酯进行治疗,观察二组患者的临床治疗效果、心绞痛症状缓解的时间、临床不良反应率,患者出院后对其随访1年,观察二组患者心血管疾病发生率。结果观察组临床显效率为95%,对照组的临床显效率为80%,二组比较差异有统计学意义(P<0.05);观察组出现恶心1例,出现头痛1例,出现眩晕1例,不良反应率为5%,对照组4例出现头痛,3例出现恶心,3例出现眩晕,不良反应率为16.67%;观察组症状缓解时间为(24±4.5)h,对照组临床症状缓解时间为(52±5.8)h,二组比较差异有统计学意义(P<0.05);随访中发现观察组心血管疾病发生率显著低于对照组,差异具有统计学意义(P<0.05)。结论采用阿托伐他汀治疗冠心病所致心绞痛具有临床疗效显著、不良反应率低以及症状缓解时间短,可显著降低心脑血管疾病等特点,值得在临床上推广应用。

Objective To explore the effects of atorvastatin for treatment of coronary heart disease due to angina pectoris. Methods From January 2011 to December 2012, 120 cases of angina pectoris came from authors hospital as the subject, the patients were random divided into the observation group and control group, 60 cases in each group. The patients in the observation group were treated with atorvastatin, control group was treated with nitric acid esters vision sorbitol dinitrate. The clinical effect in the treatment of angina pectoris symptom remission time, clinical adverse reaction rate were observed in two groups. Then the patients were followed up for 1 years and the incidence of cardiovascular disease was compared in two groups. Results The patients in the observation group showed significant clinical efficiency of 95%, but in the control group, the clinical effective rate was 80%, the difference with a significant efficiency （ P〈0.05 ）. The adverse reaction rate was 5% in the observation group, included 1 case of nausea, headache in 1 case, 1 case of dizziness; adverse reaction rate was 16. 67% in the pa- tients of control group, 4 cases in headache, 3 cases in nausea and 3 cases with vertigo. The time of symptom re- lief was （24 ± 4. 5） h in patients of observation group, but in control group, the time was （52± 5. 8） h, with a statistical difference in two groups（P〈0.05） . Follow up 1 year, the incidence of cardiovascular disease was sig- nificantly lower in observation group than in control group, the difference was statistically significant （P〈0.05）. Conclusions The effects of atorvastatin in treatment of coronary heart disease angina is significant with lower ad- verse reaction and shorter symptom relief time. It is worthy of clinical application due to significantly reduce cardi- ovascular disease.