香榧子油对实验性动脉粥样硬化形成的影响

The Preventive Effect of the Oil from the Seed of Torreya grandis cv.merrillii on Experimental Atherosclerosis in Rats

目的:从血脂、血清血栓素(TXA_2)、前列环素(PGI_2)、TXA_2/PGI_2比值及内皮素(ET)等方面探讨香榧子油对预防动脉粥样硬化形成的可能性。方法:雄性Wistar大鼠,随机分正常对照组\高脂对照组、月见草油对照组和香榧子油实验组,观察12周。结果:香榧子油实验组大鼠血清总胆固醇(TC)、甘油三酯(TG)和动脉粥样硬化指数(AI)明显低于对照组,而血清高密度脂蛋白胆固醇(HDL-C)明显高于高脂对照组;香榧子油实验组大鼠血浆TXA_2、ET水平及TXA_2/PGI_2比值低于高脂对照组,而血浆 PGI_2水平高于高脂对照组。结论:香榧子油对动脉粥样硬化形成有明显的预防作用。

Objective: To determine the preventive effect of the oil from the seed of Torreya grandis cv. merrillii (OTM) on expenmental atherosclerosis in rats. Methods: The concentration of blood lipids, plasma thromboxane (TXA2) , prostacyclin (PGI2), the ratio of TXA2/PGI2 and endothelin (ET) were investigated in maleWistar rats fed high-fat feed (HFF) containing OTM(2%) for 12 weeks.Results:OTM could reduce the level of serum total cholesterol (TC), triglyceride (TG) and the atherosclerosic index ( AI) , and increase the level of serum high-density-lipoprotein cholesterol (HDL-C) .The plasma concentration of TXA2 ,ET and the ratio of TXA2/PGI2 in group supplenented with OTM were lower than those in HFF group. Moreover, the level of plasma PGI2 was higher than that in HFF group. Conclusion:OTM is benefical in preventing atherosclerosis.