1H-茚-2-羧酸衍生物的合成与杀菌活性研究

Study on Synthesis and Fungicidal Activity of 1H-Indene-2-carboxylic Derivatives

设计、合成了10个结构新颖的1H-茚-2-羧酸衍生物,其结构经1H NMR和MS确证。初步生物活性研究结果表明所设计并合成的化合物具有杀菌活性,如化合物6h在25 mg/L剂量下,对油菜菌核病菌、黄瓜灰霉病菌的抑制率分别为87.9%和93.0%。

Ten novel 1H-indene-2-carboxylic derivatives with enamine structure were synthesized and confirmed with 1H NMR and MS spectra.The preliminary fungicidal activity results showed that the title compounds exhibited certain fungicidal activities.For example,the compound 6h showed 87.9% and 93.0% fungicidal activity against Sclerotonia sclerotiorum and Botrytis cinerea,respectively,at 25 mg/L.