(R)-(-)-α-甲氧基苯乙酸的2种合成方法

Two Synthetic Methods of (R)-2-Methoxy-2-phenylacetic Acid

(R)-(-)-α-甲氧基苯乙酸的2种合成方法均是以简单易得的扁桃酸为原料,经醚化,或者经酯化醚化、水解得单一构型(R)-(-)-α-甲氧基苯乙酸,其结构经MS、1H NMR、13C NMR分析确证。产品纯度99.3%(HPLC),反应收率52.0%。路线一方法与原有文献相比,后处理操作简单、耗时短、收率高,而路线二方法是无文献报道的全新方法。2种方法均利于工业化生产。

（R）-2-Methoxy-2-phenylacetic acid was synthesized from mandelic acid via esterification etherification and hydrolysis,or via only a single step of etherification.Its structure was confirmed by MS,1H NMR and13C NMR.The purity of the product was 99.3%（HPLC）,and overall yield was 52.0%.The former method shows the advantages of convenient operation,time saving and high yield,whereas the latter is a novel way never reported.These two methods are both suitable for industrial process.