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(R)-(-)-α-甲氧基苯乙酸的2种合成方法

Two Synthetic Methods of (R)-2-Methoxy-2-phenylacetic Acid
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摘要 (R)-(-)-α-甲氧基苯乙酸的2种合成方法均是以简单易得的扁桃酸为原料,经醚化,或者经酯化醚化、水解得单一构型(R)-(-)-α-甲氧基苯乙酸,其结构经MS、1H NMR、13C NMR分析确证。产品纯度99.3%(HPLC),反应收率52.0%。路线一方法与原有文献相比,后处理操作简单、耗时短、收率高,而路线二方法是无文献报道的全新方法。2种方法均利于工业化生产。 （R）-2-Methoxy-2-phenylacetic acid was synthesized from mandelic acid via esterification etherification and hydrolysis,or via only a single step of etherification.Its structure was confirmed by MS,1H NMR and13C NMR.The purity of the product was 99.3%（HPLC）,and overall yield was 52.0%.The former method shows the advantages of convenient operation,time saving and high yield,whereas the latter is a novel way never reported.These two methods are both suitable for industrial process.
作者 沈思思 王吕鸣 孙金涛 沙宇
机构地区 沈阳药科大学基于靶点的药物设计与研究教育部重点实验室
出处 《精细化工中间体》 CAS 2013年第2期37-38,41,共3页 Fine Chemical Intermediates
基金 辽宁省教育厅资助项目(2009226015-5)
关键词 (R)-(-)-α-甲氧基苯乙酸 扁桃酸 醚化 酯化 水解 （R）-2-methoxy-2-phenylacetic acid mandelic acid etherification esterification hydrolysis
分类号 O625.52 [理学—有机化学]
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