盐酸替罗非班的合成研究

Synthesis of Tirofiban Hydrochloride

以4-(4-哌啶基)-1-氯丁烷、L-酪氨酸等为原料经过7步反应得到盐酸替罗非班。此合成路线操作简易,总收率达21.6%,中间体及最终产物结构均经过MS和1H NMR确证。

Tirofiban hydrochloride is a reversible non-peptide platelet GP IIb/IIIa receptor antagonist,for the treatment of acute coronary syndrome. This paper reported the synthesis of Tirofiban hydrochloride from 4-（4- piperidinyl）-1-chlorobutane and L-tyrosine via 7 steps of chemical reactions. This new synthesis route with low- toxicity and simple operation has a high yield which is up to 21.6%. The structures of the intermediates and the final product were certified by MS and 1H NMR.