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盐酸帕唑帕尼的合成工艺改进 被引量：3

Synthesis of Pazopanib Hydrochloride
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摘要 以2-乙基苯胺为起始原料,经硝化、成环、甲基化、硝基还原、与2,4-二氯嘧啶取代、碘甲烷甲基化等反应制得2,3-二甲基-N-(2-氯嘧啶-4-基)-N-甲基-2H-吲唑-6-胺,再与2-甲基-5-氨基苯磺酰胺缩合、成盐制得抗肿瘤药盐酸帕唑帕尼,总收率约34.56%,其结构经1H NMR和MS确证。 Pazopanib hydrochloride,an antitumor agent,was synthesized in overall yield of 34.56% via reaction of 2,3-dimethyl-N-（2-chloropyrimidin-4-yl）-N-methyl-2H-indazol-6-amine,which was synthesized in several steps starting from 2-ethylaniline,with 2-methyl-5-aminobenzene sulfonamide.The structure was confirmed by 1H NMR and MS.
作者 王永珍 赵砚瑾 李庶心
机构地区 中南大学药学院 军事医学科学院放射与辐射药物研究所
出处 《精细化工中间体》 CAS 2013年第2期46-48,共3页 Fine Chemical Intermediates
关键词 盐酸帕唑帕尼 酪氨酸激酶抑制剂 抗肿瘤药 合成 pazopanib hydrochloride tyrosine kinase inhibitor antitumor agent synthesis
分类号 R979.1 [医药卫生—药品]
  • 相关文献

参考文献5

  • 1Sloan B,Sch einfeld N S.Pazopanib,a VEGF receptor tyrosinekinase inhibitor for cancer therapy[J].Curr Opin Investig Drugs,2008,9(12):1 324-1 335.
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  • 3陈燕,方正,韦萍.盐酸帕唑帕尼的合成[J].中国医药工业杂志,2010,41(5):326-328. 被引量：10
  • 4杨智慧,朱五福,王建强,郭飞,付强强,宫平.盐酸帕唑帕尼的工艺改进[J].精细化工中间体,2011,41(4):46-48. 被引量：4
  • 5杨欣,唐家邓,岑均达.盐酸帕唑帕尼的合成[J].中国医药工业杂志,2012,43(8):644-646. 被引量：3

二级参考文献16

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共引文献11

同被引文献24

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引证文献3

二级引证文献3

精细化工中间体
2013年 第2期

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