转录激活因子Krox-20

Research progress of activator of transcription factor Krox-20

早期生长应答基因2(early growth response 2,EGR2/Krox-20)是血清诱导的立早基因(immediate early)家族成员之一,其编码的蛋白质有3个锌指结构,可以与特异DNA序列结合,起转录激活作用。Krox-20的表达受多个信号通路的调控,进而对动物脂肪细胞的分化及神经系统的发育产生影响。对转基因鼠的研究表明,Krox-20可以促进动物脂肪形成及毛发生长等生理过程相关基因的表达,从而改良性状。本文概述了Krox-20的研究现状。

Early growth response 2 （EGR2/Krox-20） gene is one member of the immediate early gene family which is transiently activated after serum stimulation, and the Krox-20 protein, with three zinc fingers, can combine to specific DNA sequence and play the role of transcriptional activation. Its expression is regulated by multiple signaling pathways, and it is involved in animal fat cell differentiation as well as the development of nervous system. Studies on transgenic mice have indicated that Krox-20 specifically promotes the expression of certain genes which are related to the formation of animal fat, the development of hair follicle and other physiological processes. This review provides an overview of advance in study of Krox-20.