蛇毒舒缓激肽增强肽

Snake venom bradykinin potentiating peptide

舒缓激肽增强肽(bradykinin potentiating peptide,BPP)是广泛分布于蝰科(主要是蝮亚科)蛇毒中的一类小分子生物活性肽。BPP具有增强舒缓激肽以及抑制血管紧张素I转化酶(angiotensin-I converting enzyme,ACE)活性的双重毒理学作用,是造成被毒蛇咬伤时血压骤降的主要组分,也是降压药开博通(Captopril)的天然模式分子。本文简要综述了蛇毒BPP分布与种类、结构和生物学功能等方面的研究进展。

Bradykinin potentiating peptides （BPPs） represent a class of short chain peptides with multiple biological activities, which are distributed widely in the snake venoms of Viperidae （mainly Crotalinae）. BPPs can potentiate the actions of bradykinin, and can inhibit the activity of angiotensin-I converting enzyme （peptidyl-dipeptidase A） 1 （ACE）. The cooperative effects lead to lower the blood pressure in snakebite envenomation, and make it possible to be a natural lead for the anti-hypertension drug （Captopril） design. Here, we briefly review the recent advances in snake venom BPPs, including their distribution, variety, structure and biological functions.