血管内皮生长因子在食管癌中的表达和临床意义

Expression and Clinical Significance of Vascular Endothelial Growth Factor in Esophageal Carcinoma

目的 探讨食管癌血管内皮生长因子 (VEGF)、血管生成与食管癌临床病理特点的关系。方法 采用免疫组织化学技术 ,检测 5 0例食管癌组织VEGF蛋白表达和微血管密度 (MVD)。分析VEGF和MVD的关系及其与食管癌组织学分型、浸润深度、生长方式、淋巴结转移和预后的关系。结果 VEGF阳性者MVD值显著高于阴性者 ,VEGF及MVD与食管癌浸润深度、淋巴结转移密切相关 ,与组织学分型、生长方式也有明显相关性。结论 VEGF与食管癌的血管生成密切相关 ,对其生长和浸润转移起促进作用 ,VEGF可以作为食管癌生物学行为的指标之一。

Objective To approach the relationship among the vascular endothelial growth factor(VEGF),the angiogenesis and the clinical pathological characteristics of esophageal carcinoma.Methods Protein expressions of VEGF and MVD in 50 patients with esophageal cancer were determined by immunohistochemical staining.VEGF expressions were analyzed together with their relations to histologic type,depth of invasion,growth pattern,lymph node metastasis and distant metastasis.Results MVD was notable higher in VEGF -positive esophageal carcinoma than in negative group.The protein expressions of VEGF closely correlated with depth of invasion,lymph node metastasis.Their relations to the histologic types and growth pattern of esophageal carcinoma were also obviouse.Conclusion VEGF is closely related to angiogenesis of esophageal carcinoma and promotes its growth,invasion and metastasis.The expression of VEGF is one of the biological behavioral indexes of esophageal carcinoma.