鼻咽癌患者EB病毒与乙肝病毒双重感染的观察

Double Infectionin of EB Virus and HBV Patients with Nasopharyngeal Carcinoma

目的 探讨鼻咽癌患者EB病毒和乙肝病毒感染的关系。方法 检测 5 0 5 1例健康者和 12 5例鼻咽癌患者的血清EBV IgA /VCA和HBsAg。 结果 健康人群的EBV IgA/VCA和HBsAg的阳性率分别为 5 .4%和 11.3 % ;健康人群EB病毒感染者的HBsAg阳性率为 9.7% ;鼻咽癌患者的EBV IgA/VCA和HBsAg的阳性率分别为 97.6 %、2 5 .6 %。鼻咽癌EB病毒、乙肝病毒双重感染率明显高于正常对照组 (P <0 .0 1) ,呈EBV IgA /VCA抗体滴度越高越容易感染HBV的倾向。 结论 双重感染可作为鼻咽癌预后判断的参数之一。

Objective To study the relationship between EB virus and HBV infection in nasopharyngeal carcinoma(NPC).Methods Serum EBV-IgA/VCA and HBsAg were detected in l25 cases of NPC and 5051 healthy control.Results EBV and HBV infection rate in control group was 5.4% and 11.3% respectively and the double infection rate was 9.7%,while it was 97.6%(EBV) and 25.6%(HBV) in NPC,the incidence of double infection was higher compared with control( P <0.01) and there was a tendency that the higher EBV-IgA/VCA mean titer the higher HBV double infection rate was in NPC.Conclusion Double infection as a parameter can evaluate the prognosis of NPC.