胃癌患者血清G-CSF和C-反应蛋白的检测及其临床意义

Determination and significance of Serum G-CSF and CRP in Patients with Gastric Carcinoma

目的 探讨胃癌患者血清粒细胞集落刺激因子 (G CSF)和C 反应蛋白 (CRP)水平的变化及其临床意义。方法 采用ELISA法测定 47例胃癌患者血清G CSF和CRP水平 ,并与胃良性肿瘤组和正常对照组进行比较分析。结果 胃癌患者血清G CSF和CRP水平明显增高 (P <0 .0 1) ,并与疾病的临床分期和肿瘤的分化程度有关 (P <0 .0 5 ) ,病灶切除后血清G CSF和CRP水平明显降低 (P <0 .0 1)。结论 血清G CSF和CRP的水平可作为胃癌患者病情的判断和疗效观察的指标之一。

Objective To investigate the change of serum granulocyte colony-stimulating factor(G-CSF) and C-reactive protein(CRP) levels in gastric carcinoma patient.Methods Levels of serum G-CSF and CRP were detected by a sandwich ELISA in 47 cases of gastric cancer,11 cases of benign stomach tumor and 40 normal controls.Results Serum G-CSF and CRP levels in the gastric carcinoma patient were significantly higher( P <0.01),and related to staging of the disease lesion( P <0.01).After operation,serum G-CSF and CRP levels in gastric carcinoma patients significantly decreased( P <0.01).Conclusion Higher levels of serum G-CSF and CRP would associate with genesis and development of the disease,and may be as new indicators of gastric carcinoma.